What histopathological change occurs to the mucosa during inflammation?

What histopathological change occurs to the mucosa during inflammation?

• A. Thinning of the basement membrane
• B. Increased presence of eosinophils
• C. Decreased lymphocyte infiltration
• D. Reduction of cilia on the epithelial surface

Answer: (B)

The presence of eosinophils is a hallmark of inflammation, especially in conditions like asthma. During an inflammatory response, particularly in allergic reactions or asthma exacerbations, eosinophils migrate to the site of inflammation as part of the immune response. They play a significant role in combating pathogens and are also involved in tissue remodeling and the late-phase response of asthma. Increased eosinophil counts are an indicator of ongoing inflammation and can contribute to the pathophysiology of asthma by releasing inflammatory mediators and damaging the airway tissues. This infiltration is particularly significant during asthma exacerbations and can influence the severity of symptoms and airway hyperreactivity. Other options, such as thinning of the basement membrane or reduction of cilia on the epithelial surface, may occur in chronic inflammatory conditions but are not the immediate histopathological change observed during active inflammation. Likewise, decreased lymphocyte infiltration would not typically occur during inflammation, as lymphocytes are crucial players in the immune response. Understanding the role of eosinophils in inflammation can help in managing conditions like asthma, emphasizing the importance of appropriate inflammation control and therapeutic strategies.

The presence of eosinophils is a hallmark of inflammation, especially in conditions like asthma. During an inflammatory response, particularly in allergic reactions or asthma exacerbations, eosinophils migrate to the site of inflammation as part of the immune response. They play a significant role in combating pathogens and are also involved in tissue remodeling and the late-phase response of asthma.

Increased eosinophil counts are an indicator of ongoing inflammation and can contribute to the pathophysiology of asthma by releasing inflammatory mediators and damaging the airway tissues. This infiltration is particularly significant during asthma exacerbations and can influence the severity of symptoms and airway hyperreactivity.

Other options, such as thinning of the basement membrane or reduction of cilia on the epithelial surface, may occur in chronic inflammatory conditions but are not the immediate histopathological change observed during active inflammation. Likewise, decreased lymphocyte infiltration would not typically occur during inflammation, as lymphocytes are crucial players in the immune response. Understanding the role of eosinophils in inflammation can help in managing conditions like asthma, emphasizing the importance of appropriate inflammation control and therapeutic strategies.